GSBS Student Publications

Title

Amatoxin poisoning: case reports and review of current therapies

Student Author(s)

Jeanine Ward

GSBS Program

MS in Clinical Investigation

UMMS Affiliation

Department of Emergency Medicine

Date

5-1-2012

Document Type

Article

Disciplines

Emergency Medicine | Medical Toxicology

Abstract

BACKGROUND: Diagnosis and management of Amanita mushroom poisoning is a challenging problem for physicians across the United States. With 5902 mushroom exposures and two resultant deaths directly linked to Amanita ingestion in 2009, it is difficult for physicians to determine which patients are at risk for lethal toxicity. Identification of amatoxin poisoning can prove to be difficult due to delay in onset of symptoms and difficulty with identification of mushrooms. Consequently, it is difficult for the Emergency Physician to determine proper disposition. Further, treatment options are controversial.

OBJECTIVES: To review current data to help health care providers effectively identify and treat potentially deadly Amanita mushroom ingestions.

CASE REPORTS: We present two cases of Amanita mushroom ingestion in the northeastern United States treated with N-acetylcysteine, high-dose penicillin, cimetidine, and silibinin, a semi-purified fraction of milk thistle-derived silymarin, as part of their treatment regimen. The mushroom species was identified by a consultant as Amanita Ocreata.

CONCLUSIONS: We present the successful treatment of 2 patients who ingested what we believe to be an Amanita species never before identified in the northeastern United States.

Rights and Permissions

Citation: 2012 May 1. Link to article on publisher's site

DOI of Published Version

10.1016/j.jemermed.2012.02.020

Related Resources

Link to Article in PubMed

Journal Title

The Journal of emergency medicine

PubMed ID

22555054