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Student Authors
Gregory Vladimer; Dan WengUMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2013-01-11
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The inflammasome has emerged as an important molecular protein complex which initiates proteolytic processing of pro-IL-1β and pro-IL-18 into mature inflammatory cytokines. In addition, inflammasomes initiate pyroptotic cell death that may be independent of those cytokines. Inflammasomes are central to elicit innate immune responses against many pathogens, and are key components in the induction of host defenses following bacterial infection. Here, we review recent discoveries related to NLRP1, NLRP3, NLRC4, NLRP6, NLRP7, NLRP12 and AIM2-mediated recognition of bacteria. Mechanisms for inflammasome activation and regulation are now suggested to involve kinases such as PKR and PKCδ, ligand binding proteins such as the NAIPs, and caspase-11 and caspase-8 in addition to caspase-1. Future research will determine how specific inflammasome components pair up in optimal responses to specific bacteria.Source
Curr Opin Microbiol. 2013 Jan 11. doi: 10.1016/j.mib.2012.11.008.DOI
10.1016/j.mib.2012.11.008Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33270PubMed ID
23318142Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.mib.2012.11.008