GSBS Student Publications

Title

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

Student Author(s)

Chien-Min Hung

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Molecular Medicine

Date

9-5-2012

Document Type

Article

Medical Subject Headings

Adipocytes; Adipose Tissue; Adipogenesis; Myogenic Regulatory Factor 5; PTEN Phosphohydrolase

Disciplines

Cell and Developmental Biology | Life Sciences | Medicine and Health Sciences

Abstract

The developmental origin of adipose tissue and what controls its distribution is poorly understood. By lineage tracing and gene expression analysis in mice, we provide evidence that mesenchymal precursors expressing Myf5-which are thought to give rise only to brown adipocytes and skeletal muscle-also give rise to a subset of white adipocytes. Furthermore, individual brown and white fats contain a mixture of adipocyte progenitor cells derived from Myf5(+) and Myf5(neg) lineages, the number of which varies with depot location. Subsets of white adipocytes originating from both Myf5(+) and Myf5(neg) precursors respond to β(3)-adrenoreceptor stimulation, suggesting "brite" adipocytes may also have multiple origins. We additionally find that deleting PTEN with myf5-cre causes lipomatosis and partial lipodystrophy by selectively expanding the Myf5(+) adipocyte lineages. Thus, the spectrum of adipocytes arising from Myf5(+) precursors is broader than previously thought, and differences in PI3K activity between adipocyte lineages alter body fat distribution.

Comments

Citation: Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, David A. Guertin. PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors. Cell Metabolism 2012 16(3):348-362. DOI 10.1016/j.cmet.2012.08.003. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Cell Metabolism

PubMed ID

22940198