GSBS Student Publications

Title

Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes

Student Author(s)

Levi B. Watkin

UMMS Affiliation

Department of Pathology; Department of Pediatrics; Program in Molecular Medicine

Date

12-1-2010

Document Type

Article

Medical Subject Headings

Adolescent; Adult; CD8-Positive T-Lymphocytes; Clone Cells; Cross Reactions; Epitopes, T-Lymphocyte; HLA-A2 Antigen; Herpesvirus 4, Human; Humans; Immunodominant Epitopes; Influenza A virus; Middle Aged; Oligopeptides; Peptide Fragments; Receptors, Antigen, T-Cell; Viral Matrix Proteins; Young Adult

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show in this article, by examining human T cell cross-reactivity between the HLA-A2-restricted influenza A virus-encoded M1(58-66) epitope (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1(280-288) epitope (GLCTLVAML), that, under some conditions, heterologous immunity can lead to a significant broadening, rather than a narrowing, of the TCR repertoire. We suggest that dissimilar cross-reactive epitopes might generate a broad, rather than a narrow, T cell repertoire if there is a lack of dominant high-affinity clones; this hypothesis is supported by computer simulation.

Rights and Permissions

Citation: J Immunol. 2010 Dec 1;185(11):6753-64. Epub 2010 Nov 3. doi: 10.4049/​jimmunol.1000812

DOI of Published Version

10.4049/​jimmunol.1000812

Related Resources

Link to article in PubMed

Journal Title

Journal of immunology (Baltimore, Md. : 1950)

PubMed ID

21048112