Title

Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds

Student Author(s)

Tera M. Filion

GSBS Program

Cell Biology

UMMS Affiliation

Department of Orthopedics and Physical Rehabilitation; Department of Cell Biology

Date

9-1-2011

Document Type

Article

Medical Subject Headings

Biocompatible Materials; Bone Substitutes; Tissue Scaffolds; Cellulose; Surgical Mesh

Disciplines

Biology and Biomimetic Materials | Biomaterials | Cell Biology | Life Sciences | Medicine and Health Sciences | Orthopedics

Abstract

Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal-mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold.

Rights and Permissions

Citation: Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett., volume: 21, issue: 17, pages 5067-70, 2011.