GSBS Student Publications

Student Author(s)

Jessica L. Crisci

GSBS Program

Bioinformatics & Computational Biology

UMMS Affiliation

Program in Bioinformatics and Integrative Biology

Date

7-29-2011

Document Type

Article

Medical Subject Headings

Genome, Human; Biological Evolution; Selection, Genetic

Disciplines

Evolution | Genomics | Population Biology

Abstract

Ever since the first draft of the human genome was completed in 2001 there has been increased interest in identifying genetic changes that are uniquely human, which could account for our distinct morphological and cognitive capabilities with respect to other apes. Recently, draft sequences of two extinct hominin genomes, a Neanderthal and Denisovan, have been released. These two genomes provide a much greater resolution to identify human-specific genetic differences than the chimpanzee, our closest extant relative. The Neanderthal genome paper presented a list of regions putatively targeted by positive selection around the time of the human-Neanderthal split. We here seek to characterize the evolutionary history of these candidate regions - examining evidence for selective sweeps in modern human populations, as well as for accelerated adaptive evolution across apes. Results indicate that 3 of the top 20 candidate regions show evidence of selection in at least one modern human population (p

Rights and Permissions

Citation: Crisci JL, Wong A, Good JM, Jensen JD. (2011) On Characterizing Adaptive Events Unique to Modern Humans. Genome Biol Evol. First published online July 29, 2011. doi:10.1093/gbe/evr075. Link to article on publisher's website

Comments

Copyright The Author(s) 2011. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/ 2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related Resources

Link to article in PubMed

Keywords

adaptation, Neanderthal genomics, selective sweeps

Journal Title

Genome biology and evolution

PubMed ID

21803765

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