Neuronal death or dismemberment mediated by Sox14
Department of Neurobiology
Medical Subject Headings
Animals; Axons; Cell Differentiation; Dendrites; Drosophila; Drosophila Proteins; Metamorphosis, Biological; Neurons; SOXB2 Transcription Factors
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
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Citation: Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site