GSBS Student Publications

Title

Neuronal death or dismemberment mediated by Sox14

Student Author(s)

Jeannette Osterloh

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Freeman Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

11-26-2009

Document Type

Article

Medical Subject Headings

Animals; Axons; Cell Differentiation; Dendrites; Drosophila; Drosophila Proteins; Metamorphosis, Biological; Neurons; SOXB2 Transcription Factors

Disciplines

Neuroscience and Neurobiology

Abstract

The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.

Rights and Permissions

Citation: Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Nature neuroscience

PubMed ID

19935724