Title

A neural circuit mechanism integrating motivational state with memory expression in Drosophila

Student Author(s)

Michael Krashes; Shamik DasGupta

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology

Date

10-20-2009

Document Type

Article

Medical Subject Headings

Animals; Appetitive Behavior; Behavior, Animal; Conditioning, Classical; Dopamine; Drosophila Proteins; Drosophila melanogaster; Memory; Motivation; Mushroom Bodies; Neuropeptides; Receptors, Neuropeptide

Disciplines

Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology

Abstract

Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.

Rights and Permissions

Citation: Cell. 2009 Oct 16;139(2):416-27. Link to article on publisher's site

Related Resources

Link to Article in PubMed