WNTs tune up the neuromuscular junction
Department of Neurobiology
Medical Subject Headings
Animals; Humans; Neuromuscular Junction; Neuronal Plasticity; Signal Transduction; Synapses; Synaptic Transmission; Wnt Proteins
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.
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Citation: Nat Rev Neurosci. 2009 Sep;10(9):627-34. Link to article on publisher's site