GSBS Student Publications

Title

WNTs tune up the neuromuscular junction

Student Author(s)

Ceren Korkut

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Budnik Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Date

9-2009

Document Type

Article

Medical Subject Headings

Animals; Humans; Neuromuscular Junction; Neuronal Plasticity; Signal Transduction; Synapses; Synaptic Transmission; Wnt Proteins

Disciplines

Neuroscience and Neurobiology

Abstract

Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.

Rights and Permissions

Citation: Nat Rev Neurosci. 2009 Sep;10(9):627-34. Link to article on publisher's site

DOI of Published Version

10.1038/nrn2681

Related Resources

Link to Article in PubMed

Journal Title

Nature reviews. Neuroscience

PubMed ID

19693027