Title
WNTs tune up the neuromuscular junction
GSBS Program
Neuroscience
UMMS Affiliation
Department of Neurobiology
Date
8-21-2009
Document Type
Article
Medical Subject Headings
Animals; Humans; Neuromuscular Junction; Neuronal Plasticity; Signal Transduction; Synapses; Synaptic Transmission; Wnt Proteins
Disciplines
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Abstract
Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.
Rights and Permissions
Citation: Nat Rev Neurosci. 2009 Sep;10(9):627-34. Link to article on publisher's site