WNTs tune up the neuromuscular junction
Department of Neurobiology; Budnik Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Medical Subject Headings
Animals; Humans; Neuromuscular Junction; Neuronal Plasticity; Signal Transduction; Synapses; Synaptic Transmission; Wnt Proteins
Neuroscience and Neurobiology
Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.
Rights and Permissions
Citation: Nat Rev Neurosci. 2009 Sep;10(9):627-34. Link to article on publisher's site
DOI of Published Version
Nature reviews. Neuroscience
Korkut, Ceren and Budnik, Vivian, "WNTs tune up the neuromuscular junction" (2009). GSBS Student Publications. 1711.