GSBS Program
Neuroscience
UMMS Affiliation
Department of Neurobiology
Date
1-22-2010
Document Type
Article
Medical Subject Headings
Animals; Apoptosis; Brain; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Immunohistochemistry; Juvenile Hormones; Models, Biological; Nerve Tissue Proteins; Neurons; POU Domain Factors; Receptors, Notch; *Signal Transduction
Disciplines
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Abstract
Numb can antagonize Notch signaling to diversify the fates of sister cells. We report here that paired sister cells acquire different fates in all three Drosophila neuronal lineages that make diverse types of antennal lobe projection neurons (PNs). Only one in each pair of postmitotic neurons survives into the adult stage in both anterodorsal (ad) and ventral (v) PN lineages. Notably, Notch signaling specifies the PN fate in the vPN lineage but promotes programmed cell death in the missing siblings in the adPN lineage. In addition, Notch/Numb-mediated binary sibling fates underlie the production of PNs and local interneurons from common precursors in the lAL lineage. Furthermore, Numb is needed in the lateral but not adPN or vPN lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.
Rights and Permissions
Citation: Development. 2010 Jan;137(1):43-51. Link to article on publisher's site