Brudnick Neuropsychiatric Research Institute, Department of Psychiatry; Program in Molecular Medicine
Medical Subject Headings
Adaptation, Ocular; Affect; Age Factors; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Conditioning (Psychology); Electroshock; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exploratory Behavior; Fear; Food Preferences; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; Immobility Response, Tonic; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Patch-Clamp Techniques; Protein Methyltransferases; RNA, Small Interfering; Receptors, N-Methyl-D-Aspartate; Sucrose; Sweetening Agents; Transfection
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to
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Citation: J Neurosci. 2010 May 26;30(21):7152-67. Link to article on publisher's site
Jiang, Yan; Jakovcevski, Mira; Bharadwaj, Rahul; Connor, Caroline M.; Schroeder, Frederick Albert; Lin, Cong L.; Straubhaar, Juerg R.; Martin, Gilles E.; and Akbarian, Schahram, "Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B" (2010). GSBS Student Publications. Paper 1694.