Department of Neurobiology
Medical Subject Headings
Circadian Rhythm; Circadian Clocks; Aging; CLOCK Proteins; Cryptochromes; ARNTL Transcription Factors
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.
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Citation: Yu EA, Weaver DR. (2011) Disrupting the Circadian Clock: Gene-Specific Effects on Aging, Cancer, and Other Phenotypes. Aging 3(5) (advance online publication, published 5/1/11). Link to article on publisher's website