GSBS Student Publications

Student Author(s)

Elizabeth Yu

GSBS Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Weaver Lab; Graduate School of Biomedical Sciences, MD/PhD Program

Date

5-1-2011

Document Type

Article

Medical Subject Headings

Circadian Rhythm; Circadian Clocks; Aging; CLOCK Proteins; Cryptochromes; ARNTL Transcription Factors

Disciplines

Neuroscience and Neurobiology

Abstract

The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.

Rights and Permissions

Citation: Yu EA, Weaver DR. (2011) Disrupting the Circadian Clock: Gene-Specific Effects on Aging, Cancer, and Other Phenotypes. Aging 3(5) (advance online publication, published 5/1/11). Link to article on publisher's website

Journal Title

Aging

PubMed ID

21566258

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.