Menage a Trio during BMP-Mediated Retrograde Signaling at the NMJ
Department of Neurobiology
Medical Subject Headings
Bone Morphogenetic Proteins; Neuromuscular Junction; Drosophila Proteins; Guanine Nucleotide Exchange Factors; Motor Neurons; Phosphoproteins; Protein-Serine-Threonine Kinases; Synapses
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
In flies, retrograde BMP signaling is an important mechanism by which postsynaptic cells regulate the structure and function of presynaptic terminals, ostensibly through changes in gene expression. Transcriptional targets, however, have remained mysterious. In this issue of Neuron, Haghighi and colleagues begin to unravel this puzzle by identifying the cytoskeletal regulator Trio.
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Citation: Neuron. 2010 May 27;66(4):473-5. Link to article on publisher's site