Title

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment

Student Author(s)

Kavitha Narayan

UMMS Affiliation

Graduate School of Biomedical Sciences, Immunology and Virology Program; Department of Pathology

Date

8-2010

Document Type

Article

Medical Subject Headings

T-Lymphocytes; Precursor Cells, T-Lymphoid; Genes, T-Cell Receptor; Wnt Proteins

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.

Rights and Permissions

Narayan K, Kang J., Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment., Semin Immunol. 2010 Aug;22(4):222-7. Epub 2010 May 6.

Related Resources

Link to article in PubMed

Keywords

T cell development, T cell lineage commitment, T cell receptor, γδ T cells, WNT signaling

PubMed ID

20451409