Student Authors
Improgo, Ma Reina D.; Scofield, Michael D.Academic Program
NeuroscienceUMass Chan Affiliations
Gardner LabTapper Lab
Department of Psychiatry
Brudnick Neuropsychiatric Research Institute
Graduate School of Biomedical Sciences, Interdisciplinary Graduate Program
Graduate School of Biomedical Sciences, Program in Neuroscience
Document Type
Journal ArticlePublication Date
2010-06-28Keywords
Receptors, Nicotinic; Nerve Tissue Proteins; Lung Neoplasms; Tobacco Use DisorderLife Sciences
Medicine and Health Sciences
Neuroscience and Neurobiology
Oncology
Psychiatry
Metadata
Show full item recordAbstract
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the neurotransmitter, acetylcholine, and the tobacco alkaloid, nicotine. Recently, the gene cluster encoding the alpha3, alpha5 and beta4 nAChR subunits received heightened interest after a succession of linkage analyses and association studies identified multiple single-nucleotide polymorphisms in these genes that are associated with an increased risk for nicotine dependence and lung cancer. It is not clear whether the risk for lung cancer is direct or an effect of nicotine dependence, as evidence for both scenarios exist. In this study, we summarize the body of work implicating nAChRs in the pathogenesis of lung cancer, with special focus on the clustered nAChR subunits and their emerging role in this disease state.Oncogene advance online publication, 28 June 2010; doi:10.1038/onc.2010.256.Source
Improgo MRD, Scofield MD, Tapper AR, and Gardner PD. 2010. From Smoking to Lung Cancer: The Nicotinic Receptor Connection. Oncogene 29 (35): 4874-4884. DOI 10.1038/onc.2010.256. Link to article on publisher's website
DOI
10.1038/onc.2010.256Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33108PubMed ID
20581870Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/onc.2010.256