GSBS Student Publications

Student Author(s)

H. Efsun Arda; Colin C. Conine

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine



Document Type


Medical Subject Headings

Transcription Factors; Gene Regulatory Networks; Caenorhabditis elegans; Two-Hybrid System Techniques; Receptors, Cytoplasmic and Nuclear


Genetics and Genomics | Life Sciences | Medicine and Health Sciences


Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring.

Rights and Permissions

Citation: Molecular Systems Biology 6:367, doi:10.1038/msb.2010.23. Published online: 11 May 2010.

Related Resources

Link to article in PubMed



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