GSBS Student Publications

Title

Gene-centered regulatory networks

Student Author(s)

H. Efsun Arda

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Gene Function and Expression

Date

1-2010

Document Type

Article

Medical Subject Headings

Transcription Factors; Gene Expression Regulation; Gene Regulatory Networks; Caenorhabditis elegans; Two-Hybrid System Techniques

Disciplines

Genetics and Genomics | Life Sciences | Medicine and Health Sciences

Abstract

Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been made toward the mapping of GRNs using a variety of experimental and computational approaches. Here, we will discuss gene-centered approaches that we employed to characterize GRNs and describe insights that we have obtained into the global design principles of gene regulation in complex metazoan systems.

Rights and Permissions

Citation: Briefings in Functional Genomics 2010 9(1):4-12; doi:10.1093/bfgp/elp049.

Related Resources

Link to article in PubMed

Journal Title

Briefings in Functional Genomics

PubMed ID

20008400