Small silencing RNAs: an expanding universe
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Gene Expression Regulation; MicroRNAs; *Models, Genetic; *RNA Interference; RNA, Small Interfering; RNA-Induced Silencing Complex
Life Sciences | Medicine and Health Sciences
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.
Rights and Permissions
Citation: Nat Rev Genet. 2009 Feb;10(2):94-108. Link to article on publisher's site