Title

Small silencing RNAs: an expanding universe

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

1-17-2009

Document Type

Article

Medical Subject Headings

Gene Expression Regulation; MicroRNAs; *Models, Genetic; *RNA Interference; RNA, Small Interfering; RNA-Induced Silencing Complex

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.

Rights and Permissions

Citation: Nat Rev Genet. 2009 Feb;10(2):94-108. Link to article on publisher's site

Related Resources

Link to Article in PubMed