GSBS Student Publications


Small silencing RNAs: an expanding universe

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology



Document Type


Medical Subject Headings

Gene Expression Regulation; MicroRNAs; *Models, Genetic; *RNA Interference; RNA, Small Interfering; RNA-Induced Silencing Complex


Life Sciences | Medicine and Health Sciences


Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.

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Citation: Nat Rev Genet. 2009 Feb;10(2):94-108. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

Nature reviews. Genetics

PubMed ID