Title

The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development

Student Author(s)

Catherine Yin; Amanda Prince

GSBS Program

Immunology & Virology Program

UMMS Affiliation

Department of Pathology

Date

3-1-2009

Document Type

Article

Medical Subject Headings

Protein-Tyrosine Kinases; T-Lymphocytes; Signal Transduction

Disciplines

Immunology and Infectious Disease

Abstract

Tec family kinases are important components of antigen receptor signaling pathways in B cells, T cells, and mast cells. In T cells, three members of this family, inducible T-cell kinase (Itk), resting lymphocyte kinase (Rlk), and Tec, are expressed. In the absence of Itk and Rlk, T-cell receptor signaling is impaired, with defects in mitogen-activated protein kinase activation, Ca(2+) mobilization, and actin polymerization. During T-cell development in the thymus, no role has been found for these kinases in the CD4(+) versus CD8(+) T-cell lineage decision; however, several studies indicate that Itk and Rlk contribute to the signaling leading to positive and negative selection. In addition, we and others have recently described an important role for Itk and Rlk in the development of conventional as opposed to innate CD4(+) and CD8(+) T cells. Natural killer T and gammadelta T-cell populations are also altered in Itk- and Rlk/Itk-deficient mice. These findings strongly suggest that the strength of T-cell receptor signaling during development determines whether T cells mature into conventional versus innate lymphocyte lineages. This lineage decision is also influenced by signaling via signaling lymphocytic activation molecule (SLAM) family receptors. Here we discuss these two signaling pathways that each contribute to conventional versus innate T-cell lineage commitment.

Rights and Permissions

Citation: Immunol Rev. 2009 Mar;228(1):115-31. Link to article on publisher's website

Related Resources

Link to article in PubMed

Keywords

kinases, signal transduction, T-cell development