B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients
Graduate School of Biomedical Sciences; Research Division
Medical Subject Headings
Animals; Antibodies; Autoimmunity; B-Lymphocytes; Cell Differentiation; Humans; *Immunotherapy; Inflammation; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Specificity; Polyendocrinopathies, Autoimmune; T-Lymphocytes; Transcription Factors
Life Sciences | Medicine and Health Sciences
Autoimmune regulator (Aire)-deficient mice and humans have circulating autoantibodies against a multitude of organs and multiorgan autoinflammatory infiltrates. It is not known to what extent autoantibodies or their source, B lymphocytes, are required for disease onset or progression. We show in this research that B cells must be present for Aire-deficient mice to develop fulminant infiltrates. We found no evidence that autoantibodies were directly pathogenic; rather, B cells appeared to play a critical early role in T cell priming or expansion. A therapeutic reagent directed against B cells, Rituximab, induced remission of the autoimmune disease in Aire-deficient mice, raising the hope of applying it to human patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
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Citation: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13009-14. Epub 2008 Aug 28. Link to article on publisher's site
Proceedings of the National Academy of Sciences of the United States of America
Gavanescu, Irina Catrinel; Benoist, Christophe; and Mathis, Diane, "B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients" (2008). GSBS Student Publications. 1586.