GSBS Student Publications

Title

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients

UMMS Affiliation

Graduate School of Biomedical Sciences; Research Division

Date

8-30-2008

Document Type

Article

Medical Subject Headings

Animals; Antibodies; Autoimmunity; B-Lymphocytes; Cell Differentiation; Humans; *Immunotherapy; Inflammation; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Specificity; Polyendocrinopathies, Autoimmune; T-Lymphocytes; Transcription Factors

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Autoimmune regulator (Aire)-deficient mice and humans have circulating autoantibodies against a multitude of organs and multiorgan autoinflammatory infiltrates. It is not known to what extent autoantibodies or their source, B lymphocytes, are required for disease onset or progression. We show in this research that B cells must be present for Aire-deficient mice to develop fulminant infiltrates. We found no evidence that autoantibodies were directly pathogenic; rather, B cells appeared to play a critical early role in T cell priming or expansion. A therapeutic reagent directed against B cells, Rituximab, induced remission of the autoimmune disease in Aire-deficient mice, raising the hope of applying it to human patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Rights and Permissions

Citation: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13009-14. Epub 2008 Aug 28. Link to article on publisher's site

DOI of Published Version

10.1073/pnas.0806874105

Related Resources

Link to Article in PubMed

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

PubMed ID

18755889