GSBS Student Publications

Title

Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Microbiology; Program in Immunology/Virology

Date

10-11-2008

Document Type

Article

Medical Subject Headings

Aged; Antibody Formation; Humans; Immunity, Cellular; Infant; Respiratory Syncytial Virus Infections; control; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial Viruses

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants and is an important source of morbidity and mortality in the elderly and immunocompromised. This review will discuss the humoral and cellular adaptive immune responses to RSV infection and how these responses are shaped in the immature immune system of the infant and the aged environment of the elderly. Furthermore, we will provide an overview of our current understanding of the role the various arms of the adaptive immune response play in mediating the delicate balance between the successful elimination of the virus from the host and the induction of immunopathology. Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design.

Rights and Permissions

Citation: Expert Rev Vaccines. 2008 Oct;7(8):1239-55. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Expert review of vaccines

PubMed ID

18844597