Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus
UMass Chan Affiliations
Program in Immunology/VirologyDepartment of Microbiology
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2008-10-11Keywords
Aged; Antibody Formation; Humans; Immunity, Cellular; Infant; Respiratory Syncytial Virus Infections; control; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial VirusesLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants and is an important source of morbidity and mortality in the elderly and immunocompromised. This review will discuss the humoral and cellular adaptive immune responses to RSV infection and how these responses are shaped in the immature immune system of the infant and the aged environment of the elderly. Furthermore, we will provide an overview of our current understanding of the role the various arms of the adaptive immune response play in mediating the delicate balance between the successful elimination of the virus from the host and the induction of immunopathology. Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design.Source
Expert Rev Vaccines. 2008 Oct;7(8):1239-55. Link to article on publisher's siteDOI
10.1586/14760584.7.8.1239Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33015PubMed ID
18844597; 18844597Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1586/14760584.7.8.1239