GSBS Student Publications


Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity

UMMS Affiliation

Graduate School of Biomedical Sciences; Division of Rheumatology



Document Type


Medical Subject Headings

Contrast Media; Fibrosis; Gadolinium; Humans; Kidney; Kidney Failure, Chronic; Skin; Skin Diseases


Life Sciences | Medicine and Health Sciences


Nephrogenic systemic fibrosis is a devastating systemic fibrosing disorder that afflicts patients with renal dysfunction. Growing evidence supports the hypothesis that gadolinium-containing contrast agents (GCCAs) trigger the development of nephrogenic systemic fibrosis. Hence, this condition is most appropriately called gadolinium---associated systemic fibrosis (GASF). In this report, we review the history of GASF, its association with prior GCCA exposure, its clinicopathologic features, the relevant pharmacology of GCCAs, the likely role of GCCAs in its pathogenesis, and potential treatments.

Rights and Permissions

Citation: Curr Rheumatol Rep. 2008 Jul;10(3):195-204.

Related Resources

Link to Article in PubMed

Journal Title

Current rheumatology reports

PubMed ID