GSBS Student Publications

Title

Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection

UMMS Affiliation

Graduate School of Biomedical Sciences; Division of Comparative Pathology

Date

7-9-2008

Document Type

Article

Medical Subject Headings

Animals; Cell Adhesion Molecules; Cercocebus atys; Disease Progression; Down-Regulation; Lectins, C-Type; Lymphoid Tissue; Macaca mulatta; Macaca nemestrina; Mesentery; Organ Specificity; Receptors, Cell Surface; Simian Acquired Immunodeficiency; Syndrome; Simian immunodeficiency virus

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Studies were undertaken to determine whether previously described reductions in splenic DC-SIGN expression in simian acquired immune deficiency syndrome (AIDS) are limited to pathogenic simian immunodeficiency virus (SIV) infection. DC-SIGN expression was evaluated by immunohistochemistry in lymphoid tissues from AIDS-susceptible Asian macaque monkeys as compared with AIDS-resistant sooty mangabey monkeys in the presence and absence of SIV infection. The phenotype of DC-SIGN+ cells in susceptible and resistant species was identical and most consistent with macrophage identity. Significantly lower levels of DC-SIGN expression were identified in spleen, mesenteric lymph node, and bone marrow of macaques with AIDS (P<0.05). Reduced levels of splenic DC-SIGN correlated significantly with CD4T cell depletion in long-term pathogenic infection of macaques (P<0.01), whereas SIV-infected mangabeys retained high levels of DC-SIGN expression in spleen despite persistent infection. Reduced expression of DC-SIGN in spleen specifically characterizes pathogenic forms of SIV infection, correlates with disease progression, and may contribute to SIV pathogenesis.

Rights and Permissions

Citation: Dev Comp Immunol. 2008;32(12):1510-21. Epub 2008 Jul 9. Link to article on publisher's site

DOI of Published Version

10.1016/j.dci.2008.06.006

Related Resources

Link to Article in PubMed

Journal Title

Developmental and comparative immunology

PubMed ID

18606180