GSBS Student Publications

Title

Immunogenicity of DNA vaccines in humans: it takes two to tango

UMMS Affiliation

Graduate School of Biomedical Sciences; Laboratory of Nucleic Acid Vaccines; Department of Medicine

Date

4-30-2008

Document Type

Article

Medical Subject Headings

AIDS Vaccines; HIV Infections; HIV-1; Humans; *Immunization, Secondary; Plasmids; T-Lymphocytes; Vaccines, DNA; Vaccines, Subunit

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Two recently completed phase I clinical trials with candidate HIV-1 vaccines demonstrated that DNA vaccines are, indeed, immunogenic in humans, even when administered through routine needle injections. However, the best use of this evolving technology lies in its potential to prime the host's immune system. Since the discovery of DNA immunization as a new method of vaccination in the early 1990s, the real value of this technology for human vaccine development was questioned due to the apparent poor immunogenicity in repeated early phase clinical studies when DNA plasmids were injected into humans by conventional needle injections. New results indicate that DNA vaccination can provide excellent priming effects to the human immune system, and high level, antigen-specific antibody and T cell immune responses are elicited upon further stimulation through the employment of a different form of vaccine which contains antigens that match those included in the original priming DNA vaccine formulation. These findings in no way will reduce the value of DNA vaccines, instead, the roles of DNA vaccines should be redefined. It is very likely that DNA vaccine can be most useful by providing an antigen-specific immunologic help to other types of vaccines that are known to have low immunogenicity, including inactivated or recombinant protein-based subunit vaccines.

Rights and Permissions

Citation: Hum Vaccin. 2008 Nov-Dec;4(6):449-52. Epub 2008 Nov 28.

Related Resources

Link to Article in PubMed

Journal Title

Human vaccines

PubMed ID

18443427