The reprogramming language of pluripotency
Graduate School of Biomedical Sciences; Whitehead Institute for Biomedical Research
Medical Subject Headings
Animals; Disease; Humans; Nuclear Reprogramming; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; Transcription Factors
Life Sciences | Medicine and Health Sciences
In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.
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Citation: Curr Opin Genet Dev. 2008 Apr;18(2):123-9. Epub 2008 Mar 20. Link to article on publisher's site
Current opinion in genetics and development
Welstead, G Grant; Schorderet, Patrick; and Boyer, Laurie A., "The reprogramming language of pluripotency" (2008). GSBS Student Publications. 1468.