GSBS Student Publications

Title

The reprogramming language of pluripotency

UMMS Affiliation

Graduate School of Biomedical Sciences; Whitehead Institute for Biomedical Research

Date

3-22-2008

Document Type

Article

Medical Subject Headings

Animals; Disease; Humans; Nuclear Reprogramming; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; Transcription Factors

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.

Rights and Permissions

Citation: Curr Opin Genet Dev. 2008 Apr;18(2):123-9. Epub 2008 Mar 20. Link to article on publisher's site

DOI of Published Version

10.1016/j.gde.2008.01.013

Related Resources

Link to Article in PubMed

Journal Title

Current opinion in genetics and development

PubMed ID

18356040