GSBS Student Publications

Title

Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology

Date

9-1-1986

Document Type

Article

Medical Subject Headings

Animals; Bone Marrow; Cells, Cultured; *Cytotoxicity, Immunologic; H-2 Antigens; Interferon Type I; Lymphocytic Choriomeningitis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes; T-Lymphocytes, Cytotoxic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Bone marrow cells and thymocytes isolated from virus-infected or interferon (IFN)-treated mice had marked increases in sensitivity to lysis by allospecific cytotoxic T lymphocytes (CTL) and in expression of class I histocompatibility antigens. Cultured fibroblasts treated with IFN in vitro yielded similar findings in addition to having increased sensitivity to lysis by virus-specific CTL. This indicates that virus-induced IFN may condition target cells in vivo for surveillance by CTL.

Rights and Permissions

Citation: J Virol. 1986 Sep;59(3):735-9.

Related Resources

Link to article in PubMed

Journal Title

Journal of virology

PubMed ID

3488417