Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology
Medical Subject Headings
Animals; Cricetinae; Cytotoxicity, Immunologic; Female; Fibroblasts; H-2 Antigens; Immunity, Natural; Interferons; Lymphocytic Choriomeningitis; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; T-Lymphocytes, Cytotoxic; Vaccinia
Life Sciences | Medicine and Health Sciences
Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. The increased sensitivity to lysis correlated with increased expression of surface H-2 antigens, but not viral antigens. Continuous cell lines already highly sensitive to CTL-mediated lysis and already expressing high levels of surface H-2 antigens were unaffected by IFN pretreatment. These results suggest that IFN treatment, by increasing surface H-2 levels, may result in increased association of surface H-2 and virus antigens, leading to enhanced recognition and lysis by virus-specific CTL.
Rights and Permissions
Citation: J Exp Med. 1985 Jan 1;161(1):257-62.
The Journal of experimental medicine
Bukowski, Jack F. and Welsh, Raymond M., "Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells" (1985). GSBS Student Publications. 145.