GSBS Student Publications

Title

Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology

Date

1-1-1985

Document Type

Article

Medical Subject Headings

Animals; Cricetinae; Cytotoxicity, Immunologic; Female; Fibroblasts; H-2 Antigens; Immunity, Natural; Interferons; Lymphocytic Choriomeningitis; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; T-Lymphocytes, Cytotoxic; Vaccinia

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. The increased sensitivity to lysis correlated with increased expression of surface H-2 antigens, but not viral antigens. Continuous cell lines already highly sensitive to CTL-mediated lysis and already expressing high levels of surface H-2 antigens were unaffected by IFN pretreatment. These results suggest that IFN treatment, by increasing surface H-2 levels, may result in increased association of surface H-2 and virus antigens, leading to enhanced recognition and lysis by virus-specific CTL.

Rights and Permissions

Citation: J Exp Med. 1985 Jan 1;161(1):257-62.

Related Resources

Link to article in PubMed

Journal Title

The Journal of experimental medicine

PubMed ID

2578543