GSBS Student Publications

Title

The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine

Date

2-13-2008

Document Type

Article

Medical Subject Headings

Adult; Age Factors; Aged; Alleles; Cohort Studies; DNA Mutational Analysis; Drug Resistance; Female; Humans; Hydroxyurea; Janus Kinase 2; Male; Middle Aged; *Mutation, Missense; Platelet Count; *Point Mutation; Polycythemia Vera; Primary Myelofibrosis; Treatment Outcome

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

JAK2V617F-positive patients with essential thrombocythemia, as opposed to their mutation-negative counterparts, require lower doses of hydroxyurea (HU) for control of their platelet count. In the current study, we looked for predictors of HU response in 69 patients with primary myelofibrosis (PMF) and 56 with polycythemia vera (PV). JAK2V617F analysis was performed on bone marrow-derived DNA obtained at or near the time of diagnosis. HU response in PMF was associated with a shorter disease duration (P = 0.008), absence of previous therapy (P = 0.01), older age at diagnosis (P = 0.009), and presence of JAK2V617F (P = 0.02). On multivariable analysis, only the latter retained its significance (48% vs. 8% response in mutation positive vs. negative cases). In PV, JAK2V617F allele burden correlated directly with HU response (P = 0.05) and inversely with daily HU dose in responding patients (P = 0.02). The current study suggests that JAK2V617F presence identifies PMF patients who are likely to respond to HU therapy, and information on its allele burden helps in assigning the optimal starting dose in individual patients with PV.

Rights and Permissions

Citation: Am J Hematol. 2008 May;83(5):363-5. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

American journal of hematology

PubMed ID

18266209