The pluripotency regulator Oct4: a role in somatic stem cells
The Whitehead Institute for Biomedical Research
Medical Subject Headings
Animals; Embryonic Stem Cells; Humans; Mice; Octamer Transcription Factor-3; Pluripotent Stem Cells; Signal Transduction
Life Sciences | Medicine and Health Sciences
Since its discovery as a critical regulator of pluripotency in embryonic stem (ES) cells and the inner cells mass of the developing blastocyst, the Pou domain-containing transcription factor Oct4 has become a proxy for "stemness" in numerous studies of somatic stem cells as its presence is often taken as evidence of pluripotency in these cells. Recent studies, however, have demonstrated that not only is Oct4 dispensable for maintaining potency in somatic stem cell compartments, but also that the methods applied to detect Oct4 and the interpretation of the resulting data may be flawed. Here we contrast pathways known to govern pluripotency in embryonic stem cells with those in adult stem cells and critically discuss the concept of pluripotency in adult stem cells of the mammalian soma.
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Citation: Cell Cycle. 2008 Mar 15;7(6):725-8. Epub 2008 Jan 14.
Cell cycle (Georgetown, Tex.)
Lengner, Christopher Joachim; Welstead, G. Grant; and Jaenisch, Rudolf, "The pluripotency regulator Oct4: a role in somatic stem cells" (2008). GSBS Student Publications. 1441.