Title

Elevated levels of soluble ST2 protein in dengue virus infected patients

UMMS Affiliation

Center for Infectious Disease and Vaccine Research

Date

1-30-2008

Document Type

Article

Medical Subject Headings

Adolescent; Adult; Child; Dengue; Female; Humans; Male; Middle Aged; Receptors, Cell Surface

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Levels of the soluble form of the interleukin-1 receptor-like 1 protein (IL-1RL-1/ST2) are elevated in the serum of patients with diseases characterized by an inflammatory response. The objective of this study was to determine the concentration of soluble ST2 (sST2) in dengue infected patients during the course of the disease. Twenty-four patients with confirmed dengue infection, classified as dengue fever, and 11 patients with other febrile illness (OFI) were evaluated. Levels of sST2 in serum and laboratory variables usually altered during dengue infections were measured. Dengue infected patients had higher serum sST2 levels than OFI at the end of the febrile stage and at defervescence (p=0.0088 and p=0.0004, respectively). Patients with secondary dengue infections had higher serum sST2 levels compared with patients with primary dengue infections (p=0.047 at last day of fever and p=0.030 at defervescence). Furthermore, in dengue infected patients, we found a significant negative correlation of sST2 with platelet and WBC counts, and positive correlation with thrombin time and transaminases activity. We suggest that sST2 could be a potential marker of dengue infection, could be associated with severity or could play a role in the immune response in secondary dengue virus infection.

Rights and Permissions

Citation: Cytokine. 2008 Feb;41(2):114-20. Epub 2008 Jan 28. Link to article on publisher's site

Related Resources

Link to Article in PubMed