GSBS Student Publications


Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology



Document Type


Medical Subject Headings

Animals; Cytomegalovirus Infections; Female; Interferon Type I; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Poly I-C; Vaccinia


Life Sciences | Medicine and Health Sciences


Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.

Rights and Permissions

Citation: J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.

Related Resources

Link to article in PubMed

Journal Title

The Journal of general virology

PubMed ID