GSBS Student Publications

Title

Cancer targeting using tumor suppressor genes

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

11-6-2007

Document Type

Article

Medical Subject Headings

Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Gene Therapy; *Genes, Tumor Suppressor; *Genes, p53; Humans; Immunotherapy; Lung Neoplasms; Models, Biological; Neoplasms; Viral Vaccines

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drugs that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

Rights and Permissions

Citation: Front Biosci. 2008 Jan 1;13:1959-67.

Related Resources

Link to Article in PubMed

Journal Title

Frontiers in bioscience : a journal and virtual library

PubMed ID

17981683