Cancer targeting using tumor suppressor genes
Department of Molecular Genetics and Microbiology
Medical Subject Headings
Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Gene Therapy; *Genes, Tumor Suppressor; *Genes, p53; Humans; Immunotherapy; Lung Neoplasms; Models, Biological; Neoplasms; Viral Vaccines
Life Sciences | Medicine and Health Sciences
Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drugs that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.
Rights and Permissions
Citation: Front Biosci. 2008 Jan 1;13:1959-67.
Frontiers in bioscience : a journal and virtual library
Chada, Sunil; Menander, Kerstin B.; Bocangel, Dora B.; Roth, Jack A.; and Ramesh, Rajagopal, "Cancer targeting using tumor suppressor genes" (2007). GSBS Student Publications. 1417.