Hepcidin regulation of iron transport
Graduate School of Biomedical Sciences; Department of Exercise and Nutrition Sciences
Medical Subject Headings
Antimicrobial Cationic Peptides; Biological Transport; Gene Expression Regulation; Homeostasis; Humans; Iron
Life Sciences | Medicine and Health Sciences
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
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Citation: J Nutr. 2008 Nov;138(11):2284-8. Link to article on publisher's site