Title
Hepcidin regulation of iron transport
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Exercise and Nutrition Sciences
Date
10-22-2008
Document Type
Article
Medical Subject Headings
Antimicrobial Cationic Peptides; Biological Transport; Gene Expression Regulation; Homeostasis; Humans; Iron
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
Rights and Permissions
Citation: J Nutr. 2008 Nov;138(11):2284-8. Link to article on publisher's site