Title

Hepcidin regulation of iron transport

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Exercise and Nutrition Sciences

Date

10-22-2008

Document Type

Article

Medical Subject Headings

Antimicrobial Cationic Peptides; Biological Transport; Gene Expression Regulation; Homeostasis; Humans; Iron

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.

Rights and Permissions

Citation: J Nutr. 2008 Nov;138(11):2284-8. Link to article on publisher's site

Related Resources

Link to Article in PubMed