GSBS Student Publications

Title

Post-transcriptional regulation of myelin formation

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Pharmacology

Date

7-2-2008

Document Type

Article

Medical Subject Headings

Animals; Axons; Brain; Fragile X Mental Retardation Protein; Gene Expression Regulation; Mice; Mice, Quaking; Myelin Sheath; Oligodendroglia; RNA-Binding Proteins; Signal Transduction

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Myelin is a specialized structure of the nervous system that both enhances electrical conductance and protects neurons from degeneration. In the central nervous system, extensively polarized oligodendrocytes form myelin by wrapping cellular processes in a spiral pattern around neuronal axons. Myelin formation requires the oligodendrocyte to regulate gene expression in response to changes in its extracellular environment. Because these changes occur at a distance from the cell body, post-transcriptional control of gene expression allows the cell to fine-tune its response. Here, we review the RNA-binding proteins that control myelin formation in the brain, highlighting the molecular mechanisms by which they control gene expression and drawing parallels from studies in other cell types.

Rights and Permissions

Citation: Biochim Biophys Acta. 2008 Aug;1779(8):486-94. Epub 2008 Jun 11. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Biochimica et biophysica acta

PubMed ID

18590840