GSBS Student Publications

Title

Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients

UMMS Affiliation

Graduate School of Biomedical Sciences; Center for Infectious Disease and Vaccine Research

Date

7-11-2008

Document Type

Article

Medical Subject Headings

CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Epitopes, T-Lymphocyte; HLA-A2 Antigen; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Vaccines, Inactivated; Viral Matrix Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.

Rights and Permissions

Citation: J Virol. 2008 Sep;82(18):9283-7. Epub 2008 Jul 9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Journal of virology

PubMed ID

18614638