GSBS Student Publications

Title

Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein

Student Author(s)

Elizabeth Ann Corey

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

1-1-2009

Document Type

Article

Medical Subject Headings

Hemagglutinins, Viral; Measles virus; Mutation, Missense; Viral Fusion Proteins; Virus Attachment

Disciplines

Life Sciences | Medicine and Health Sciences | Virology

Abstract

Fusion promotion by measles virus (MV) depends on an interaction between the hemagglutinin (H) and fusion (F) glycoproteins. Amino acid substitutions in MV H that drastically reduce hemagglutinating activity result in an increase in the amount of H (primarily the 74 kDa isoform) detectable in a complex with F at the cell surface. This is in direct contrast to the loss of the ability to detect a complex between the fusion protein of Newcastle disease virus and most attachment proteins that lack receptor binding activity. These opposing results provide support for the existence of different mechanisms for the regulation of fusion by these two paramyxoviruses.

Rights and Permissions

Citation: Virology. 2009 Jan 5;383(1):1-5. Epub 2008 Nov 14. Link to article on publisher's site

DOI of Published Version

10.1016/j.virol.2008.10.018

Related Resources

Link to Article in PubMed

Journal Title

Virology

PubMed ID

19013625