Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein
Molecular Genetics & Microbiology
Department of Molecular Genetics and Microbiology
Medical Subject Headings
Hemagglutinins, Viral; Measles virus; Mutation, Missense; Viral Fusion Proteins; Virus Attachment
Life Sciences | Medicine and Health Sciences | Virology
Fusion promotion by measles virus (MV) depends on an interaction between the hemagglutinin (H) and fusion (F) glycoproteins. Amino acid substitutions in MV H that drastically reduce hemagglutinating activity result in an increase in the amount of H (primarily the 74 kDa isoform) detectable in a complex with F at the cell surface. This is in direct contrast to the loss of the ability to detect a complex between the fusion protein of Newcastle disease virus and most attachment proteins that lack receptor binding activity. These opposing results provide support for the existence of different mechanisms for the regulation of fusion by these two paramyxoviruses.
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Citation: Virology. 2009 Jan 5;383(1):1-5. Epub 2008 Nov 14. Link to article on publisher's site
Corey, Elizabeth Ann and Iorio, Ronald M., "Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein" (2009). GSBS Student Publications. 1372.