Title
Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
GSBS Program
Cell Biology
UMMS Affiliation
Department of Cell Biology
Date
8-11-2008
Document Type
Article
Medical Subject Headings
Animals; Cell Nucleus; *Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Neoplasms; Transcription Factors
Disciplines
Cancer Biology | Cell Biology | Life Sciences | Medicine and Health Sciences
Abstract
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
Rights and Permissions
First published as: J Cell Biochem. 2008 Aug 15;104(6):2016-26. Link to article on publisher's site