Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
Department of Cell Biology
Medical Subject Headings
Animals; Cell Nucleus; *Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Neoplasms; Transcription Factors
Cancer Biology | Cell Biology | Life Sciences | Medicine and Health Sciences
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
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First published as: J Cell Biochem. 2008 Aug 15;104(6):2016-26. Link to article on publisher's site