GSBS Student Publications

Title

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Student Author(s)

Sandhya Pande

GSBS Program

Cell Biology

UMMS Affiliation

Department of Cell Biology

Date

8-11-2008

Document Type

Article

Medical Subject Headings

Animals; Cell Nucleus; *Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Neoplasms; Transcription Factors

Disciplines

Cancer Biology | Cell Biology | Life Sciences | Medicine and Health Sciences

Abstract

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

Rights and Permissions

First published as: J Cell Biochem. 2008 Aug 15;104(6):2016-26. Link to article on publisher's site

DOI of Published Version

10.1002/jcb.21813

Related Resources

Link to Article in PubMed

Journal Title

Journal of cellular biochemistry

PubMed ID

18615590