GSBS Student Publications

Title

In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences

Date

3-20-1998

Document Type

Article

Medical Subject Headings

Animals; Corpus Striatum; Dopamine; Female; *Fetal Tissue Transplantation; Mesencephalon; Nerve Endings; Parkinson Disease, Secondary; imaging; Rats; Rats, Sprague-Dawley; *Tomography, Emission-Computed

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Positron emission tomography (PET) and carbon-11-labeled 2B-carbomethoxy-3B-(4-fluorophenyl)tropane (11C-CFT or 11-WIN 35,428) were used as molecular markers for striatal presynaptic dopamine (DA) transporters in a unilateral Parkinson's disease rat neurotransplantation model. In the lesioned striatum, the binding ratio measured by the DA presynaptic marker was reduced to 15% to 35% of the intact side (or unoperated control). After grafting with non-DA cells (from dorsal mesencephalon), the DA binding ratio remained reduced to levels observed before transplantation and rats showed no behavioral recovery. In contrast, after DA neuronal transplantation, behavioral recovery occurred only after the 11C-CFT binding ratio had increased to 75% to 85% of the intact side. This study provides direct in vivo evidence for the dopaminergic molecular basis of functional recovery in the lesioned nigrostriatal system after neural transplantation.

Rights and Permissions

Citation: Ann Neurol. 1998 Mar;43(3):387-90. Link to article on publisher's site

DOI of Published Version

10.1002/ana.410430318

Related Resources

Link to article in PubMed

Journal Title

Annals of neurology

PubMed ID

9506557