Apoptosis and loss of virus-specific CD8+ T-cell memory
Graduate School of Biomedical Sciences; Department of Pathology
Medical Subject Headings
Animals; Apoptosis; CD8-Positive T-Lymphocytes; Clonal Anergy; Humans; *Immunologic Memory; Interferon Type II; Listeria Infections; Listeria monocytogenes; Mice; Tumor Necrosis Factor-alpha; Virus Diseases; Viruses
Life Sciences | Medicine and Health Sciences
CD8(+) T-cell memory to viruses is stable in the absence but volatile in the presence of other infections. Apoptotic events that occur early in acute infections delete pre-existing memory T cells, leaving the host with reduced memory (except for cross-reactive responses) to previously encountered viruses. Apoptotic events also silence the acute immune response, leaving the host with a residual population of memory T cells. Persistent infections can induce apoptotic deletions of memory T cells that are specific to the persisting virus and to previously encountered pathogens.
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Citation: Curr Opin Immunol. 2004 Jun;16(3):271-6. Link to article on publisher's site
Current opinion in immunology
Welsh, Raymond M.; Bahl, Kapil; and Wang, Xiaoting Z., "Apoptosis and loss of virus-specific CD8+ T-cell memory" (2004). GSBS Student Publications. 1334.