GSBS Student Publications

Title

Receptor activation of G proteins

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry; Department of Biochemistry and Molecular Pharmacology

Date

10-1-1988

Document Type

Article

Medical Subject Headings

Amino Acid Sequence; Animals; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Molecular Sequence Data; Receptors, Adrenergic; Receptors, Muscarinic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

G proteins are a highly conserved family of membrane-associated proteins composed of alpha, beta, and gamma subunits. The alpha subunit, which is unique for each G protein, binds GDP or GTP. Receptors such as those for beta- and alpha-adrenergic catecholamines, muscarinic agonists, and the retinal photoreceptor rhodopsin, catalyze the exchange of GDP for GTP binding to the alpha subunit of a specific G protein. G alpha.GTP regulates appropriate effector enzymes such as adenylyl cyclase or the cyclic GMP phosphodiesterase. The beta gamma-subunit complex of G proteins is required for efficient receptor-catalyzed alpha subunit guanine nucleotide exchange and also functions as an attenuator of alpha subunit activation of effector enzymes. Recent elucidation of both receptor and G protein primary sequence has allowed structural predictions and new experimental approaches to study the mechanism of receptor-catalyzed G protein regulation of specific effector systems and the control of cell function including metabolism, secretion, and growth.

Rights and Permissions

Citation: FASEB J. 1988 Oct;2(13):2841-8.

Related Resources

Link to Article in PubMed

Journal Title

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

PubMed ID

3139484