GSBS Student Publications

Title

Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

5-20-2003

Document Type

Article

Medical Subject Headings

Animals; Annexin A5; Apoptosis; Arenaviridae Infections; CD8-Positive T-Lymphocytes; Cell Survival; *Immunologic Memory; *Lymphocytic choriomeningitis virus; Lymphoid Tissue; Mice; Organ Specificity

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apoptotic marker Annexin-V than those in spleen and lymph nodes. This was not due to a TCR-based selection. In comparison to lymphoid tissue, T cells in the periphery expressed lower levels of Fas and Fas ligand and were resistant to activation-induced cell death in vitro. This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis.

Rights and Permissions

Citation: Immunity. 2003 May;18(5):631-42.

Related Resources

Link to Article in PubMed

Journal Title

Immunity

PubMed ID

12753740