Interferon regulatory factors: growth control and histone gene regulation--it's not just interferon anymore
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Animals; Cell Cycle; Cell Division; DNA-Binding Proteins; *Gene Expression Regulation; Genes, Tumor Suppressor; Histones; Humans; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferons; Oncogenes; Phosphoproteins; *Repressor Proteins; *Transcription Factors; Transcription, Genetic
Life Sciences | Medicine and Health Sciences
Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the beta-interferon gene and many interferon-stimulated genes. Two well-studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-beta gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1, IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.
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Citation: J Mol Med. 1997 May;75(5):348-59.
Journal of molecular medicine (Berlin, Germany)
Vaughan, Patricia S.; Van Wijnen, Andre J.; Stein, Janet L.; and Stein, Gary S., "Interferon regulatory factors: growth control and histone gene regulation--it's not just interferon anymore" (1997). GSBS Student Publications. 1308.