GSBS Student Publications

Title

Interferon regulatory factors: growth control and histone gene regulation--it's not just interferon anymore

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Date

5-1-1997

Document Type

Article

Medical Subject Headings

Animals; Cell Cycle; Cell Division; DNA-Binding Proteins; *Gene Expression Regulation; Genes, Tumor Suppressor; Histones; Humans; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferons; Oncogenes; Phosphoproteins; *Repressor Proteins; *Transcription Factors; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the beta-interferon gene and many interferon-stimulated genes. Two well-studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-beta gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1, IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

Rights and Permissions

Citation: J Mol Med. 1997 May;75(5):348-59.

Related Resources

Link to Article in PubMed

Journal Title

Journal of molecular medicine (Berlin, Germany)

PubMed ID

9181476