Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology,
Medical Subject Headings
Animals; Antigens, Viral; CD4-Positive T-Lymphocytes; Cells, Cultured; Complementarity Determining Regions; Female; Immunoglobulin Variable Region; Immunologic Memory; Lung; Lymphocyte Activation; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Receptors, Antigen, T-Cell, alpha-beta; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; T-Lymphocyte Subsets; Th2 Cells; Viral Proteins
Life Sciences | Medicine and Health Sciences
Vaccination with the respiratory syncytial virus (RSV) attachment (G) protein results in immune-mediated lung injury after natural RSV infection with pathogenic features characteristic of an exaggerated Th2 response. Here we demonstrate that approximately half of the CD4(+) T cells infiltrating the lungs of G-primed mice utilize a single V beta gene (V beta 14) with remarkably limited CDR3 diversity. Furthermore, elimination of these V beta 14-bearing CD4(+) T cells in vivo abolishes the type 2-like pulmonary injury. These results suggest that a novel subset of CD4(+) T cells may be crucial in the development of pathology during human RSV infection and that genetic or environmental factors prior to or at the time of G antigen exposure may affect the commitment of this discrete antigen-specific T cell subset to Th2 differentiation.
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Citation: Immunity. 2001 Oct;15(4):637-46.
Varga, Steven Michael; Wang, Xiaoting Z.; Welsh, Raymond M.; and Braciale, Thomas J., "Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells" (2001). GSBS Student Publications. 1299.