The role of dynein in retrograde axonal transport
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Adenosine Triphosphatases; Animals; Axonal Transport; Brain; Dynein ATPase; Models, Neurological; Neurons
Life Sciences | Medicine and Health Sciences
Fast axonal transport is manifested at the sub-cellular level as the anterograde or retrograde movement of membrane-bounded organelles along microtubules. Earlier work implicated the protein kinesin as the motor for anterograde axonal transport. More recent work indicates that a brain microtubule-associated protein, MAP 1C, is responsible for retrograde transport. Of additional interest, MAP 1C has been found to be a cytoplasmic form of the ciliary and flagellar ATPase dynein, indicating a much more general functional role for this enzyme in cells than had been suspected.
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Citation: Trends Neurosci. 1989 Feb;12(2):66-70.
Trends in neurosciences
Vallee, Richard B.; Shpetner, Howard S.; and Paschal, Bryce Mark, "The role of dynein in retrograde axonal transport" (1989). GSBS Student Publications. 1274.