GSBS Student Publications

Title

Induction of angiosarcoma by a c-erbB transducing virus

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

5-1-1985

Document Type

Article

Medical Subject Headings

Animals; Avian Leukosis; Avian leukosis virus; Base Sequence; Chickens; Hemangiosarcoma; *Transduction, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Recently, 12 new transductions of c-erbB have been identified in a series of Rous-associated virus type 1-induced erythroleukemias. During the passage of these new transducing viruses it has become apparent that the erythroleukemia in chicken 5005 contained two different c-erbB transducing viruses. One induces erythroblastosis, whereas the second induces angiosarcoma. The angiosarcoma- and erythroblastosis-inducing viruses appear to have had a common ancestor, since tumors induced by each contain a novel, 4.3-kilobase c-erbB-related EcoRI fragment. The angiosarcoma-inducing virus has been named avian angiosarcoma virus and is designated for the chicken in which it originated.

Rights and Permissions

Citation: J Virol. 1985 May;54(2):304-10.

Related Resources

Link to Article in PubMed

Journal Title

Journal of virology

PubMed ID

2985799