GSBS Student Publications

Title

Effects of striatal excitotoxicity on huntingtin-like immunoreactivity

UMMS Affiliation

Graduate School of Biomedical Sciences; Neuroregeneration Laboratory

Date

5-30-1995

Document Type

Article

Medical Subject Headings

Animals; Antibodies; Cell Death; Corpus Striatum; Excitatory Amino Acids; Gene Expression; Huntington Disease; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Mutation; Nerve Tissue Proteins; Neurons; Neurotoxins; Nuclear Proteins; Putamen; Quinolinic Acid

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The relationship between the specific neuronal loss observed in Huntington's disease and the mutation in the IT15 gene responsible for this disease remains obscure. Using an antipeptide antibody against amino acids 3114-3141 of the human huntington protein, we demonstrate that striatal injection of quinolinic acid in mice induces increased immunoreactivity for huntington in some remaining neurons but not in glial cells. This increase is apparent in both neuronal cell bodies and in cell processes in the white matter six hours after excitotoxic challenge. This finding suggests that huntington may be involved in the response to excitotoxic stress in these neurons.

Rights and Permissions

Citation: Neuroreport. 1995 May 30;6(8):1125-9.

Related Resources

Link to Article in PubMed

Journal Title

Neuroreport

PubMed ID

7662892