Student Authors
Calin StoicovUMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
2006-03-25Keywords
Animals; Bone Marrow Cells; Cell Differentiation; Cell Transformation, Neoplastic; Humans; Stomach NeoplasmsGastroenterology
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Cells derived from bone marrow are pluripotent, with the ability to differentiate into multiple cell types. Environmental cues dictate differentiation decisions. It should not be surprising then, that abnormal cell environments lead to abnormal differentiation of these cells, and in some cases, malignant transformation. Identifying a role for bone marrow-derived cells in the initiation and progression of cancer allows a dramatic change in the way in which cancer is viewed. Identifying the cell responsible for initiating a tumor offers the exciting possibility of specifically targeting unique aspects of these cells and altering signaling properties for more effective therapeutic approaches.Source
Future Oncol. 2005 Dec;1(6):851-62. Link to article on publisher's siteDOI
10.2217/14796694.1.6.851Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32646PubMed ID
16556065Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.2217/14796694.1.6.851