Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair
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Authors
Stein, Gary S.Zaidi, Sayyed K.
Braastad, Corey D.
Montecino, Martin A.
Van Wijnen, Andre J.
Choi, Je-Yong
Stein, Janet L.
Lian, Jane B.
Javed, Amjad
Document Type
Journal ArticlePublication Date
2003-10-24Keywords
Animals; Apoptosis; Cell Nucleus; DNA Methylation; *DNA Repair; *DNA Replication; *Gene Expression Regulation; Humans; Models, Genetic; Nuclear MatrixLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.Source
Trends Cell Biol. 2003 Nov;13(11):584-92.
DOI
10.1016/j.tcb.2003.09.009Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32634PubMed ID
14573352Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.tcb.2003.09.009