Title
Insight into regulatory factor targeting to transcriptionally active subnuclear sites
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology
Date
12-2-1999
Document Type
Article
Medical Subject Headings
Biological Transport; *Bone Development; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; *Hematopoiesis; Transcription Factors
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture contribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provide insight into the trafficking of the hematopoietic and bone-specific AML/CBF family of regulatory factors to transcriptionally active subnuclear sites.
Rights and Permissions
Citation: Exp Cell Res. 1999 Nov 25;253(1):110-6. Link to article on publisher's site