Title

Insight into regulatory factor targeting to transcriptionally active subnuclear sites

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Date

12-2-1999

Document Type

Article

Medical Subject Headings

Biological Transport; *Bone Development; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; *Hematopoiesis; Transcription Factors

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture contribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provide insight into the trafficking of the hematopoietic and bone-specific AML/CBF family of regulatory factors to transcriptionally active subnuclear sites.

Rights and Permissions

Citation: Exp Cell Res. 1999 Nov 25;253(1):110-6. Link to article on publisher's site

Related Resources

Link to Article in PubMed