Insight into regulatory factor targeting to transcriptionally active subnuclear sites
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Biological Transport; *Bone Development; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; *Hematopoiesis; Transcription Factors
Life Sciences | Medicine and Health Sciences
Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture contribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provide insight into the trafficking of the hematopoietic and bone-specific AML/CBF family of regulatory factors to transcriptionally active subnuclear sites.
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Citation: Exp Cell Res. 1999 Nov 25;253(1):110-6. Link to article on publisher's site